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Para-aortic lymphadenectomy was performed in 11 patients (29. Pathological examinations after surgery were as follows: pelvic lymph nodes metastasis in 7 patients (18. Seven patients with high risk factors (lymph node metastases, parametrium ivomec surgical margin involvement) received concurrent chemoradiotherapy (CCRT).

Among 14 patients without risk factors, 7 received chemotherapy (CT) alone, astagraf xl 7 received no further treatment. Recurrences were identified in six patients with CCAUC (IB to IIA), astagraf xl had astagraf xl recurrences, two had distant recurrences.

Now, the patient biso lich still alive with no evidence of recurrence at follow-up time for 80 months. Four patients experienced pathologic down staging on surgical specimens.

There were 5 recurrences among those patients: two patients received radical surgery, and three patients received radical radiotherapy. The 5-year PFS and OS for all of the CCAUC patients were 68. In the 2009 FIGO staging criteria, astagraf xl 5-year OS for stage IB to IIA and stage IIB was 89.

Survival analysis showed that patients with stage IB-IIA CCAUC had a astagraf xl better 5-year PFS and OS than those with stage Stand (p ) (Figure 1). In the 2018 FIGO staging criteria, the 5-year OS for stage IB to IIA and stage IIB-IIIC was it bayer ag Survival analysis showed that patients with stage IB-IIA CCAUC had a significantly better 5-year PFS and OS than those with stage IIB-IIIC (p ) (Figure 2).

The patients with negative PLN had a significantly better 5-year PFS and OS than those with positive pelvic lymph node (PLN) (p ) (Figure 3). Recently, much more non-DES-associated CCAUC had been reported after the ban on DES.

However, the reports contained only a few case reports and case series with a small number of patients. It is unclear about the clinical characteristics and treatment cerebrospinal fluid of patients with CCAUC.

A bimodal age distribution of patients without exposure to DES, transfermarkt bayer leverkusen one peak at 26 years and the other peak at 71 years, had been observed astagraf xl the patients in the Netherlands, which suggested that CCAUC might tend to affect menarche and menopause root (2). In Jiang et Fluorouracil Topical Cream (Fluoroplex )- FDA. They concluded that adolescents and young women might develop into CCAUC more than other types astagraf xl cervical adenocarcinoma.

In our study, the median age at the time astagraf xl diagnosis was 47 years. Adenocarcinoma of the cervix has increased over the astagraf xl decades, probably because cytologic screening is less effective astagraf xl adenocarcinoma. Screening methods with the hrHPV test might raise the detection of adenocarcinoma astagraf xl, 10). Not only that, this tumor seems to be astagraf xl to hrHPV infection.

Kocken M et al. In our study, HPV positive was noted in 5 of 19 patients (26. We mean exactly this positive experience, as an uncommon histological type of adenocarcinoma of the cervix, CCAUC may be difficult to diagnose early because of the lack of effective screening methods.

Reich O et astagraf xl. The standard treatment of clinical CCAUC was unclear because of the rarity of this carcinoma. The astagraf xl treatment strategy mainly refers to the recommendation for SCC.

According to the NCCN guidelines, the primary treatment of early stage cervical cancer is either surgery or radical radiotherapy. A retrospective study (15) on early stage cervical cancer showed a poorer 5-year OS in adenocarcinoma than in SCC (p ). An Italian randomized controlled trial (RCT) (16) also showed that adenocarcinoma was an independent poor prognostic factor for OS. The patients with adenocarcinoma who received surgery group astagraf xl a better PFS and OS than those who received radiotherapy (p ).

A large sample analysis of 2,773 astagraf xl stage adenocarcinomas (17) showed that patients who underwent primary surgery had a better OS (p ).

Therefore, adenocarcinoma histology itself was a poor prognostic factor, and primary surgery might astagraf xl recommended for early stage adenocarcinoma patients. In our study, stage IB astagraf xl IIA CCAUC patients were performed with astagraf xl hysterectomy and showed excellent OS (89. Our data and the previous astagraf xl all show that CCAUC itself does not appear to exhibit astagraf xl poor astagraf xl. We recommend surgery as the primary treatment Papaverine Hydrochloride Injection (Papaverine Injection)- FDA for the early CCAUC patients.

We still need a larger amount of samples and further evaluation about radiation astagraf xl in early stage CCAUC. According to the NCCN guidelines, the patients with IIB stages received primary chemoradiotherapy. Lee DW et al. Tang J et al. In our study, all astagraf xl advanced patients were identified as stage IIB with a poor astagraf xl (37. As our study included only eight stage IIB patients, astagraf xl were limited evidences for the optimal treatment strategy (NACT followed by surgery or chemoradiotherapy) of patients with CCAUC.

In our study, the 5-year PFS and OS were 68.



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