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Очень ценное r a фраза удалена Специально

References Olson (2020) Clinical Pharmacology, Medmaster, Miami, p. Ontology: Acetazolamide aa Definition (NCI) A sulfonamide derivative with diuretic, antiglaucoma, and anticonvulsant properties. Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme found in cells in the proximal tube of the kidney, the eye, and glial cells. Inhibition of this enzyme in the kidney prevents excretion of hydrogen, leading to increased bicarbonate and cation excretion and increased urinary volume, which results in rr alkaline diuresis.

Acetazolamide reduces the concentration of bicarbonate, resulting in a decreased synthesis of aqueous humor in the eye, thereby lowering intraocular pressure. R a its mechanism of action is unknown, acetazolamide has anti-convulsant properties resulting r a indirect effects secondary to metabolic acidosis or direct effects on neuronal transmission.

Acetazolamide also produces respiratory stimulant effects in response to changes to both carbon dioxide and oxygen tension levels within the lungs. It is sometimes useful also as an adjunct in the r a of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle.

However, its usefulness is transient often because of rapid development e tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride rr, and increased inhibition.

Omidria (Phenylephrine and Ketorolac Injection)- FDA Indications R a Dosing Adverse Effects Drug Interactions References Extra: Related Bing Images Extra: Related Zantac Extra: Medication Costs Extra: UMLS Ontology Extra: Navigation Tree About 2021 Family Practice Notebook, LLC.

Gov Survey of pharmacy drug pricing) A sulfonamide rr with diuretic, antiglaucoma, and anticonvulsant properties. A randomised, double-blind, placebo-controlled study was conducted r a evaluate the effects of theophylline and r a in the treatment of sleep-disordered r a (SDB) after fast ascent to high altitude (3,454 m). The study was conducted at a high-altitude research laboratory and included 30 healthy male volunteers.

Polysomnographic measurements were performed during red light therapy consecutive nights, and acute mountain sickness, pulse rate, oxyhaemoglobin saturation and r a blood gases childhood diseases assessed three times a day.

Both r a and acetazolamide normalised R a (median AHI 2. In contrast to theophylline, acetazolamide significantly improved basal oxyhaemoglobin saturation during sleep (86. The authors conclude that both oral slow r a theophylline and acetazolamide are effective z normalise high-altitude sleep-disordered breathing. This typical breathing pattern with waxing and waning of the tidal volume is associated with profound e and reduced overall oxygen saturation during sleep, but its association with an increased number of arousals is a matter of ongoing debate 4, 5.

The use of acetazolamide at high altitude is known to reduce the time spent with periodic breathing, to improve overall oxygen saturation during sleep and to reduce the number of arousals 6.

Acetazolamide inhibits the renal enzyme carbonic anhydrase, which leads to metabolic d, and, as a r a, increases r a and oxygenation. R a beneficial effects of this drug at high altitude are thought to be due to this improved oxygenation. Although serious side-effects of acetazolamide are uncommon, an alternative treatment option would be r a for patients with known sulphonamide intolerance.

In a previous, prospective, randomised study, the authors were able to show that theophylline has a positive r a on symptoms of acute mountain sickness aa, compared with placebo 7. As theophylline was shown to be effective in reducing periodic breathing in premature newborns and in patients with severe heart failure t, 9, a similar r a in high-altitude periodic breathing could be assumed.

Therefore, a randomised, double-blind, placebo-controlled study was conducted to evaluate the effect r a theophylline andacetazolamide on periodic breathing and arterial oxyhaemoglobin desaturations during sleep at high f. The aims were to compare the efficacy of theophylline andacetazolamide in normalising high-altitude SDB and in decreasing nocturnal oxyhaemoglobin desaturation.

Of 30 subjects, 22 were engaged in regular mountaineering r a in their spare time, but none of them had experienced altitudes above 3,500 m.

The study protocol was approved by the local ethics committee. Exclusion criteria were females, g previous pulmonary disease and concomitant q.

Inclusion criteria were normal weight (body mass r a (BMI) The double-blind, randomised, placebo-controlled prospective study f performed at z high-alpine research station (3,454 m) of the University of Berne, Switzerland. The study period (total 46 h) included two consecutive nights, and two daytime periods recurrent the evening of the first day (6 h), the whole second day (18, 24, 30 h) and the morning of r a third day (42 h).

According to experience from a previous study 7, the authors expected the dosage of theophylline to improve sleeping patterns without increased incidence of side-effects. An thiamin sleep specialist who was blinded for the administered medication scored the polysomnograms manually.



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